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The principal cytochrome P450 isoenzyme involved seems for being CYP2E1, with CYP1A2 and CYP3A4 as further pathways. About eighty five% of the oral dose seems while in the urine within just 24 hours of administration, most since the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity de